Protein Modification Reagents
ILEX LIFE SCIENCES LLC Cellendes ToLuminate PEG Photogel Photocrosslinkable 1/EA
ToLuminate PEG Photogel Kit photo-crosslinkable hydrogel DESCRIPTION The ToLuminate PEG Photogel Kit manufactured by Cellendes GmbH provides reagents for setting up cell-compatible hydrogels formed by illumination with blue light (365-405 nm) on the basis of the thiol-ene chemistry Its major components are norbornene-modified dextran (N-Dextran) and the thiol-modified cross-linker PEG-Link When the two reagents are combined and illuminated in the presence of LAP (Lithium phenyl-2 4 6-trimethyl benzoyl phosphinate) thiol groups on PEG-Link are activated and form stable thioether bonds with norbornene groups on N-Dextran The components are mixed at physiological pH (pH 7 2) for optimal cell compatibility There is ample time to place the pre-gel solution in any culture dish or container since gelation starts only after illumination Cell adhesion peptides can be covalently attached to N-Dextran to provide a cell-adhesive matrix QUANTITY Up to 4 ml hydrogel
Medchemexpress LLC Fluorescein-PEG4-acid | 1807518-76-8 | 96.3% | 654.68 | 25 MG
Fluorescein-PEG4-acid is a PEG-based PROTAC linker. It can be used in the synthesis of PROTACs, which are compounds containing two different ligands connected by a linker. One ligand is for an E3 ubiquitin ligase and the other is for the target protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
Medchemexpress LLC DBCO-PEG2-NHS ester | 2585653-12-7 | 849001 | C30H31N3O8 | 25 MG
DBCO-PEG2-NHS ester is a click chemistry reagent that contains an azide group and an NHS ester. The NHS ester reacts specifically and efficiently with primary amines under neutral or slightly basic conditions to form a covalent bond. The hydrophilic PEG spacer arm enhances water solubility and provides a long, flexible connection to minimize steric hindrance. DBCO is used for copper-free Click Chemistry reactions. It is intended for research use only.
- Contains an azide group and an NHS ester
- NHS ester reacts specifically and efficiently with primary amines
- Hydrophilic PEG spacer arm enhances water solubility
- Minimizes steric hindrance in ligation
- Used for copper-free click chemistry reactions
- Reagent grade
- For research use only
Epigentek Inc DTT Solution (1 ml, 500 mM)
DTT, also known as Cleland's Reagent, is a particularly strong reducing agent, owing to its high conformational proprensity to form a six member ring with an internal disulfide bond. It has a redox potential of -0.33 V @ pH 7. It is used for many protein research applications, including reducing polyacrylamide electrophoresis (SDS-PAGE). The 500 mM stock solution can be directly used to achieve the amount of reducing agent required for your specific application.
ABclonal Technology HIF1/ARNT Rabbit mAb
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus where it promotes the expression of genes involved in xenobiotic metabolism This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1 Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias Alternative splicing results in multiple transcript variants
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | 98.9% | 1 G
N3-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). It is a click chemistry reagent containing an azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Non-cleavable 4-unit PEG linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions