Protein Modification Reagents
Medchemexpress LLC Chloroacetamido-PEG4-C2-Boc | 1365655-90-8 | ≥97.0% | 250 MG
Chloroacetamido-PEG4-C2-Boc is a PROTAC linker that belongs to the PEG and Alkyl/ether class. This linker, which includes tetraethylene glycol, is suitable for the synthesis of various PROTAC molecules.
- Used in the synthesis of PROTACs
- PROTACs connect two distinct ligands: one targeting an E3 ubiquitin ligase, the other a specific protein
- Leverages the intracellular ubiquitin-proteasome system
- Facilitates the selective degradation of target proteins
Medchemexpress LLC Tos-PEG4-NH-Boc (PROTAC Linker 7) | 1246999-33-6 | ≥98.0% | 250 MG
Tos-PEG4-NH-Boc is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These molecules are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Utilizes the ubiquitin-proteasome system
- Selectively degrades target proteins
- Consists of two different ligands connected by a linker
- One ligand binds to an E3 ubiquitin ligase
- Other ligand binds to the target protein
Medchemexpress LLC DBCO-PEG24-maleimide | 2924872-84-2 | 98.0% | 1555.81 | C76H122N4O29 | 5mg
DBCO-PEG24-Maleimide contains a maleimide and a DBCO group DBCO-PEG24-Maleimide can be used for thiol-containing biomolecule conjugations DBCO-PEG24-Maleimide can be used in click chemistry with azide-bearing biomolecules[1]
Medchemexpress LLC NH-bis(C2-PEG2-NH-Boc) | 2182601-69-8 | 99.9% | 50 MG
NH-bis(C2-PEG2-NH-Boc) is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to contain two different ligands connected by a linker, allowing for the exploitation of the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs.
- Functions as a PEG-based PROTAC linker.
- Targets PROTAC linkers and PROTAC pathways.
- Applicable in cancer-programmed cell death.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ABclonal Technology SF3B6 Rabbit pAb
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site.
Cayman Chemical Boc-NH-PEG3-CH2CoH 100mg
A building block; has been used as a linker in the synthesis of PROTACs targeting MEK; has been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and GRPR in tumor tissue in vivo
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG5-CH2COOH | 50 g | CAS 635287-26-2 | InChIKey LNIFRTLAPAPKAG-UHFFFAOYSA-N
Fmoc-NH-PEG5-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 50 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 635287-26-2
- MDL: No data
- InChIKey: LNIFRTLAPAPKAG-UHFFFAOYSA-N
- Molecular Weight: 517.575
- Molecular Formula: C27H35NO9
- Purity: ≥95%
- Container Type: 250 mL HDPE
- Pack Size: 50 g
- Net Weight: 50 g
- Gross Weight: 89.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid
- SMILES: O=C(COCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Chemscene ChemScene | DBCO-PEG4-NHS ester | 50MG | CS-0114458 | 0.98 | 1427004-19-0| MFCD26793797 | 649.69
ChemScene | DBCO-PEG4-NHS ester | 50MG | CS-0114458 | 0.98 | 1427004-19-0| MFCD26793797 | 649.69
Medchemexpress LLC 2-((1E,3Z)-3-(1-(1-((E)-Cyclooct-2-en-1-yloxy)-1,12-dioxo-5,8-dioxa-2,11-diazaheptadecan-17-yl)-3,3- | 91.1% | 775.46 | C45H63ClN4O5 | 10 MG
Cy3-PEG2-TCO is a Cy3-based fluorescent reagent containing a two-unit PEG spacer and a trans-cyclooctene (TCO) functional group. It is designed for rapid bioorthogonal conjugation via inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-bearing partners and is intended for research use in labeling, imaging, and bioconjugation workflows.
- Fluorescent Cy3 dye derivative suitable for imaging and labeling.
- PEG2 spacer improves solubility and reduces steric hindrance during conjugation.
- TCO functional group enables fast, selective iEDDA click reactions with tetrazines.
- Supplied as a solid with color ranging brown to reddish brown.
- High purity (~91.1%) with molecular weight 775.46 g·mol-1.
- Store protected from light under nitrogen at -20°C; in solvent, store at -80°C for long term.
Medchemexpress LLC Bis-PEG4-PFP ester | 1314378-12-5 | 97.0% | 100 MG
Bis-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker.
- Can be used in the synthesis of protacs.
Sigma Aldrich Fine Chemicals Biosciences Collagenase P from Clostri
Collagenase P is an enzyme mixture prepared from the extracellular culture filtrate of a special Clostridium histolyticum strain.Collagenase P is a research biochemical not manufactured under the US good manufacturing practices (GMP) regulations.Note Collagenase P is a non-sterile preparation of the culture supernatant of Clostridium histolyticum. It is neither designed nor intended for isolation of pancreatic islets for transplantation into humans and must not be used for such purposes.
Medchemexpress LLC S-acetyl-dPEG4-NHS ester | 937025-17-7 | MFCD11041102 | 98.0% | 421.46 g/mol | C17H27NO9S | 10 MG
S-acetyl-dPEG4-NHS ester is a discrete polyethylene glycol reagent that installs a protected thiol group via an N-hydroxysuccinimide (NHS) ester. It is used to thiolate proteins, peptides, and small molecules to enable downstream conjugation and crosslinking in bioconjugation and drug-delivery research. The reagent is supplied as a solid with reported purity and molecular weight.
- Protected thiol for controlled thiolation reactions.
- NHS-ester reactive group for efficient coupling to amines.
- Discrete PEG4 spacer improves solubility and reduces steric hindrance.
- Facilitates protein, peptide, and small-molecule conjugation.
- Suitable for bioconjugation and drug-delivery research workflows.
- Supplied as a stable solid suitable for storage and handling.